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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2013 May 30;64:61–68. doi: 10.1016/j.freeradbiomed.2013.05.034

Figure 4.

Figure 4

Network scheme for deriving miR-regulated networks and signaling pathways. Cells are subjected to shear stress for various time points and analyzed experimentally with proteomic tools to assess PTM-mediated regulation of signaling pathways. PTM Scout is integrated in this assessment, following which transcription factors regulating miR transactivation can be investigated utilizing experimental and bioinformatics approaches. This data are cross referenced with FIRM analysis, and can be utilized, with assistance from KeyMolnet, to construct miR-regulated networks.