Fig. 2.
Spontaneous breathing mechanics in mice after sham thoracotomy, PNX, or PNX + PNT. Plethysmography measurements were obtained of tidal volume (VT, A), breathing frequency (f, B), and minute ventilation (MV, C) for 21 days after surgery. The only significant difference between experimental groups was the decrease in VT and MV of the PNX + PNT group compared with the sham thoracotomy group on day 1 after surgery (*P < 0.05). D: after 21 days, a trend toward an increase in the MV of the sham thoracotomy group relative to the PNX and PNX + PNT groups was not significant (P > 0.05). Each data point represents the mean of multiple measurements/mouse; n = 4–5 mice studied at each time point. Error bars reflect 1 SD.