Fig. 5.

Body weight and body composition before and after switching to standard diet or high-protein diet. After development of diet-induced obesity on Western-type diet or feeding of standard diet for 9 wk (A), rats were fed a standard or high-protein diet, resulting in four experimental groups: standard diet/standard diet, standard diet/high-protein diet, Western-type diet/standard diet, and Western-type diet/high-protein diet. Body composition was assessed in conscious lightly restrained (∼1 min) rats directly before switching diets and after the 14-day measurement period on day 15 using quantitative nuclear magnetic resonance analysis. Changes of total body weight (B), fat mass (C and D), lean mass (E), and water (F) were assessed. Data are expressed as means ± SE of 8–10 rats/group. **P < 0.01 and ***P < 0.001 vs. standard diet/standard diet; +P < 0.05 and +++P < 0.001 vs. standard diet/high-protein diet; #P < 0.05 vs. Western-type diet/standard diet.