Fig. 1.
Left: data for mean arterial pressure (MAP) in wild-type vs. obese, leptin-deficient ob/ob mice (81). Right: systolic arterial pressure (AP) in wild-type vs. skinny, hyperleptinemic transgenic mice overexpressing leptin from a liver promoter (1). Obese leptin-deficient mice had lower AP than wild-type controls, whereas skinny hyperleptinemic mice had higher AP than wild-type controls. Tg, transgenic. *P < 0.05. [Adapted from Aizawa-Abe et al. (1) and Mark et al. (81).].