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Changes in MAP (top) and renal sympathetic nerve activity (SNA; bottom) in diet-induced obese hypertensive rabbits after cerebroventricular administration of vehicle, a leptin antagonist, or an insulin antagonist (76). The leptin antagonist produced significant (***P < 0.001) decreases in MAP and renal SNA, whereas the insulin antagonist produced a smaller decrease in MAP (*P < 0.05) and did not decrease renal SNA.
