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Schematic diagram depicting several leptin-STAT3 and leptin-PI3K-mediated actions with emphasis on the differential regional SNA actions. STAT3 mediates increases in brown adipose tissue (BAT) SNA, whereas PI3K increases white adipose tissue (WAT) SNA but not BAT SNA. PI3K mediates leptin-induced increases in renal SNA, whereas STAT3 does not. Nevertheless, both STAT3 and PI3K mediate leptin-induced increases in blood pressure.
