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Top: changes in renal SNA in Sprague-Dawley rats after cerebroventricular administration of leptin (vehicle-leptin), losartan (losartan-vehicle), or leptin following losartan (losartan-leptin). Leptin alone increased renal SNA. Losartan blocked leptin-induced increases in renal SNA. Losartan alone had no significant effect on renal SNA. As depicted in the schematic (lower panel), these studies suggest that brain AT1R mediate the renal SNA responses to leptin (62).
