Table 3.
Occurrence of arrhythmogenesis (AT or AF) under different protocols
| Agents | Intrinsic (n) | Regular pacing (10 Hz) (n) | PES (n) |
|---|---|---|---|
| Control | 0 (36) | 0 (36) | 3 (36) |
| FPL | 3 (7)** | 4 (7)** | 7 (7)** |
| Nifedipine pre-treated | 0 (12)* | 0 (12)* | 3 (12)## |
| CPA pre-treated 20 min | 0 (11)* | 0 (11)* | 1 (11)*** |
| Caffeine pre-treated >15 min | 0 (6)* | 0 (6)* | 0 (6)*** |
| Nifedipine + FPL | 0 (6)* | 0 (6)* | 5 (6)** |
| CPA + FPL | 0 (6)* | 0 (6)* | 4 (6)** |
| Caffeine + FPL | 0 (6)* | 0 (6)* | 1 (6)## |
AT, atrial tachycardia; AF, atrial fibrillation; CPA, cyclopiazonic acid; PES, programmed electrical stimulation.
Test agents vs. control P < 0.01**; test agents vs. FPL P < 0.05*; test agents vs. FPL P < 0.01## and P < 0.001*** on Fisher exact testing. Each entry provides both the incidence of arrhythmogenesis and the number of hearts studied in brackets.