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Peroxynitrite (ONOO−) detoxification by Peroxiredoxin II E (PrxIIE) is regulated by S-nitrosylation. NO and O2− can rapidly react to form toxic ONOO−, which is detoxified by PrxIIE. Pathogen infection triggers the parallel burst of NO and O2− and thus presumably increases the amount of cellular ONOO−. Further, increasing amounts of NO may promote S-nitrosylation of PrxIIE, which inhibits its activity leading to increased ONOO− levels.
