Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The role of Mn antioxidants and SOD enzymes in microbial pathogenesis. During infection, the host defense response includes the oxidative burst by macrophages and neutrophils involving the NADPH oxidase production of O2•−. To evade the host response, microbes (white circle) employ SOD enzymes as well as Mn antioxidants (see main text). Since O2•− is not membrane permeable, extracellular/periplasmic microbial antioxidant defenses may be most critical.
