Table 4. Univariate and multivariate analysis for clinical and MRD variables of RFS and OS.

Variables	RFS			OS
	Univariate analysis	Multivariate analysis		Univariate analysis	Multivariate analysis
	P-value	P-value	OR (95% CI)	P-value	P-value	OR (95% CI)
Gender	0.440	NS	—	0.668	NS	—
Age	0.187	NS	—	0.791	NS	—
WBC count	0.003	NS	—	0.280	NS	—
Hb level	0.552	NS	—	0.442	NS	—
Platelets count	0.016	NS	—	0.431	NS	—
BM blasts	0.842	NS	—	0.099	NS	—
Late CR	<0.001	NS	—	0.138	NS	—
B-ALL subtype	0.552	NS	—	0.692	NS	—
Consolidation therapya	0.009	NS	—	0.224	NS	—
BCR-ABL-positive	0.273	NS	—	0.681	NS	—
Number of LAIPs	0.440	NS	—	0.612	NS	—
MRD positiveb at the end of induction	<0.001	0.002	4.427 (1.750–11.197)	<0.001	NS	—
MRD positive after one consolidation	<0.001	<0.001	9.832 (4.545–21.268)	<0.001	<0.001	5.652 (2.739–11.662)
Undetectable MRD at the end of induction	<0.001	NS	—	<0.001	NS	—

Abbreviations: B-ALL, B-lineage acute lymphoblastic leukemia; BM, bone marrow; CI, confidence interval; CR, complete remission; Hb, hemoglobin; LAIP, leukemia-associated immunophenotype; MRD, minimal residual disease; NS, not significant; OR, odds ratio; OS, overall survival; RFS, relapse-free survival; WBC, white blood cell.

^aAllogeneic stem cell transplantation or chemotherapy.

^bMRD⩾0.01%.