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. 2013 Aug 15;4(8):e771. doi: 10.1038/cddis.2013.299

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Role of GluR6-containing kainate receptor in the denitrosylation and activation of procaspase-3 during I/R in hippocampus. (a) Procaspase-3 denitrosylation, (b) procaspase-3 activation, (c) expression of FasL, (d) expression of Trx2 were measured followed by 3 h reperfusion (a) or 6 h reperfusion (b–d). NS102 (10 mM), an antagonist of GluR6, was administrated 30 min before ischemia. The samples were processed using the biotin switch method followed by western blotting. NS102 almost prevented the denitrosylation and activation of procaspase-3 and the upregulated expression of FasL and Trx-2 after I/R. n=4; *P<0.05 compare with sham group, ^#P<0.05 compare with DMSO (I/R) group. Data are represented as means±S.D.