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. 2013 Aug 29;4(8):e781. doi: 10.1038/cddis.2013.303

Figure 3.

Figure 3

RPE permeability is induced through a VEGFR-2/Src pathway. Western blot analysis showed a three-fold increase in phosphor-Tyr416-Src (P-Src) expression 6 h after LD in the eye-cup (a), as well as in the neural retina (b). The expression of VEGFR-1 decreased significantly and progressively down to 28% of basal level at 48 h after LD (c). At 24 and 36 h after LD, VEGFR-2 expression was decreased by 45 and 35%, respectively, and seemed to return to basal level at 48 h (19% decrease, not significant – d). Quantification results are expressed as percentage of the control group. Protein expression level was normalized against values of tubulin, GAPDH or actin controls to adjust for protein loading. Results are expressed as mean±S.D. (n=6 per group). Statistical analyses: one-way ANOVA followed by Bonferoni's post hoc test: *P<0.05 and **P<0.01 (no LD: control group unexposed to light)