Figure 7.

Blocking VEGF in the LD model preserved visual acuity. The optokinetic response (OR) was quantified in the following experimental groups: no treatment prior to LD (a), Sham- (b), LV-GFP- (c) and LV-V65 (d)-treated groups. The quantification of the OR was measured at the beginning of the experiment (prior the injection and LD), 2 weeks after subretinal injection and 10 days after LD. Statistical analysis presented in the figures compared OR before and after light exposures. Results show that the subretinal injection did not affect OR in the different injected groups (b–d), except in the LV-V65-treated group for 0.075 cpd. Contrariwise, 10 days after light exposure, ORs recorded in the control groups (no treatment prior to LD and Sham-injected) were significantly impaired and no difference was observed compared with background value. OR was still present but decreased in the LV-GFP-treated group after LD. Blocking VEGF preserved OR after light exposure in the LV-V65-treated group. Results are expressed as mean±S.E. Statistical analyses: one-way ANOVA and Tukey's post hoc test: n.s.: nonsignificant, *P<0.05, **P<0.01 and ***P<0.001 (n=8 per group)