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The active site of EF-Tu during decoding. A) Superposition of the GTPase centers from the isolated TC (grey)(19) and the TC-GDPCP-ribosome (red). Small movements are observed for hydrophobic gate residues Val20 and Ile60. B) GTPase activation allows the phosphate of A2662 of the SRL (orange) to position His84 into the active site. After GTP hydrolysis (15) and Pi release Switch I becomes disordered (dashed-line) and His84 rotates away from GTP.
