Table 2.
Most significantly regulated gene categories
| GO category | p valuea |
|---|---|
| Second-messenger-mediated signaling | 1.62E-16 |
| Intracellular signaling cascade | 3.89E-16 |
| Protein kinase C activation | 1.45E-15 |
| Muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway | 2.19E-15 |
| Learning and/or memory | 1.91E-14 |
| Positive regulation of mismatch repair | 6.61E-13 |
| Negative regulation of protein ubiquitination | 6.61E-13 |
| Negative regulation of protein modification | 6.61E-13 |
| Regulation of mismatch repair | 6.61E-13 |
| Dopamine transport | 8.71E-13 |
| Wnt receptor signaling pathway | 1.41E-12 |
| Regulation of cell differentiation | 1.91E-12 |
| Negative regulation of enzyme activity | 2.45E-12 |
| Negative regulation of biological process | 3.80E-12 |
| Signal transduction | 1.10E-11 |
| Cell communication | 2.14E-11 |
| Negative regulation of protein amino acid phosphorylation | 2.82E-11 |
| Negative regulation of amino acid metabolic process | 2.82E-11 |
| Cell–cell signaling | 3.63E-11 |
| Cell surface receptor-linked signal transduction | 3.89E-11 |
| Regulation of developmental process | 4.37E-11 |
| Regulation of peptidyl-tyrosine phosphorylation | 4.57E-11 |
| Negative regulation of cellular process | 7.76E-11 |
| Tissue remodeling | 9.12E-11 |
| Regulation of signal transduction | 1.05E-10 |
ap values were calculated using Gene Go software with a false discovery rate cutoff of 0.01. Overall, 113 GO categories showed p values <1E-6, and 271 had p values <1E-4.