Table 4.
Expression of stresscopin and CRF-related genes in MDD
| Category | Gene | GenBank ID | Description | Fold changes | p value |
|---|---|---|---|---|---|
| CRH system | CRH | BC011031 | Corticotropin-releasing hormone | 1.00 | NS |
| UCN | NM_003353 | Urocortin | 1.10 | NS | |
| SRP | NM_033199 | Stresscopin-related peptide (urocortin 2) | 1.13 | NS | |
| SPC | NM_053049 | Stresscopin (urocortin 3) | 1.99 | <0.05* | |
| CRHR1 | NM_004382 | Corticotropin-releasing hormone receptor 1 | 0.81 | NS | |
| CRHR2 | NM_001883 | Corticotropin-releasing hormone receptor 2 | 0.95 | NS | |
| CRHBP | BC018038 | Corticotropin-releasing hormone-binding protein | 0.85 | NS | |
| Glucocorticoid | NR3C1 | NM_000176 | Glucocorticoid receptor | 1.11 | NS |
| NR3C2 | NM_000901 | Mineralocorticoid receptor | 1.16 | NS | |
| GMEB1 | AF099013 | Glucocorticoid modulatory element binding protein 1 | 1.08 | NS | |
| GMEB2 | AF173867 | Glucocorticoid modulatory element binding protein 2 | 1.05 | NS | |
| GRLF1 | NM_004491 | Glucocorticoid receptor DNA binding factor 1 | 1.16 | NS |
Expression of stresscopin and CRF-related genes were examined by microarray analysis. The results are expressed as mean ± SEM. An asterisk indicates significant at p value indicated (unpaired t test). NS, Not significant.