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Conformational selection by differential binding of PEG to the propeller quadruplex. (A) Representative fit of titration data obtained for PEG600 to Equation (7) (squares, 265 nm; circles, 290 nm). Optimized parameters were Keq,0 = 0.147, n = 4 and KB = 0.41 ± 0.01 M for the binding affinity of PEG 600. (B) Molecular dynamics shows PEG 600 interacts favorably with the planar G-tetrad faces of the propeller structure.
