Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Clamp-loading mechanism and subsequent exchange of the clamp loader with DNA polymerase on the sliding clamp. In the presence of ATP, the clamp loader binds and opens the ring-shaped DNA sliding clamp for its loading on the DNA. Then the clamp loader hydrolyzes ATP to ADP before its dissociation from the clamp–DNA complex. In the final step, DNA polymerase binds the clamp and starts the DNA replication.
