Table 2.
Examples of GPCRs coupling to certain G Protein subclasses (Gi, Gs and Gq).
| G Protein | Receptor Subtypes | References |
|---|---|---|
| Gi protein | Chemokine Receptor | [82] |
| Opioid Receptor | [83] | |
| Somatostatin Receptor | [84] | |
| Neuropeptide Y Receptor | [85] | |
| Melatonin Receptor | [86] | |
| Cannabinoid Receptor | [87] | |
| Sphingosine-1-phosphate Receptor | [88] | |
| Histamine Receptor | [87] | |
| 5-hydroxytryptamine | [89] | |
| Dopamine Receptor | [87] | |
| Muscarinic Receptor | [90,91] | |
| Formyl-methionyl peptide Receptor | [92] | |
| Gs protein | Vasopressin receptor 2 | [87] |
| Adrenoceptors | [93] | |
| Prostaglandin E receptor subtypes | [94] | |
| 5-hydroxytryptamine receptor subtypes | [89] | |
| Melanocyte-stimulating hormone receptor | [95] | |
| Melanocortin receptor subtypes | [96] | |
| Relaxin receptor subtypes | [97] | |
| Adenosine receptor | [98] | |
| Gq protein | Vasopressin receptor subtypes (V1a and V1b) | [87,99] |
| Muscarinic acetylcholine receptor subtypes | [90] | |
| Gonadotropin-releasing hormone receptor | [100] | |
| P2Y purinoceptor subtypes | [101,102] | |
| Bradykinin receptor subtypes | [103] | |
| Oxytocin receptors subtypes | [99] | |
| Gastrin/cholecystokinin type B receptor | [104] | |
| Neuromedin U Receptor subtypes | [105] | |
| Neurotensin Receptor | [106] | |
| Gi/s proteins | Glycoprotein hormone receptors | [107] |
| β-Adrenoceptors | [108,109] | |
| Gi/q proteins | Platelet activating factor receptor | [87] |
| Sphingolipid (S1P3)/Lysophospholipid receptor (LPA2) | [81] | |
| Galanin receptor 2 | [110] | |
| Endothelin B | [111] | |
| Gq/s proteins | Calcitonin Receptor | [112] |
| Parathyroid hormone receptor | [113] | |
| Cholecystokinin-Areceptor | [87] | |
| Gq/i/s proteins | Prostaglandin E3 receptor | [94] |
| Thyrotropin receptor | [107] | |
| Luteinizing hormone receptor | [87] | |
| Lysophospholipid receptor subtypes | [114,115] |