Table 1.

Current clinical trial status of TRPV1 and somatostatin modulators developed by different drug discovery companies.

Compound name	Brand name	Molecular mechanism	Company	Route of administration	Indication	Stage
Capsaicin	Qutenza	TRPV1 agonist	NeurogesX	Topical patchesTopical cream	Neuropathic pain	Launched
Zucapsaicin	Zuacta	TRPV1 agonist	Winston Laboratories	Topical cream	Osteoarthritis	Launched
SB-705498	―	TRPV1 antagonist	GlaxoSmithKline	Intranasal	Rhinitis	Phase II
PAC-14028	―	TRPV1 antagonist	AmorePacific	Oral	Atopic dermatitis	Phase I
SYL-1001	―	TRPV1 expression inhibitor	Sylentis	Ophthalmic	Dry eyePain	Phase I
DG-3173	―	Somatostatin analog	Evotec	Subcutaneous	Diabetic retinopathy	Phase I