Table 1.
Co-chaperones of Hsp90.
| Co-chaperone | Function |
|---|---|
| Cdc37 | Interacts with protein kinases |
| p23 | Facilitates the maturation of client proteins |
| Aha1 | Stimulates Hsp90 ATPase activity |
| SGT1 | Binds to Hsp90 N-terminal domain, and inhibits Hsp90 ATPase activity |
| HOP | Delivers steroid hormone receptor clients to Hsp90, and also mediates the binding of Hsp90 and Hsp70 |
| TAH1 | TPR containing protein, inhibits Hsp90 ATPase activity by forming cochaperone complex with PIH1 |
| CHIP | Is an E3 ubiquitin ligase, and regulates the balance of folding/degradation for Hsp90 clients |
| FKBP51/52 | Mediates the interaction of steroid receptor with Hsp90 |
TAH1, TPR-containing protein associated with Hsp90; TPR, TetratricoPeptide Repeat; PIH1, protein interacting with Hsp90; CHIP, Carboxyl terminus of Hsc70-interacting protein; FKBP, FK506-binding protein.