Table 2.
Pharmacokinetic Parameters for Bupropion and Metabolites (mean, 95% CI)
| All (N=42) | No reduced function allele (N=16) | With reduced function allele(s) (N=26) | *6 allele (N= 23) | *18 allele (N= 2) | *6/18 allele (N= 1) | |
|---|---|---|---|---|---|---|
| BUP | ||||||
| Cmax (ng/mL) | 58 (52,63) | 58 (51,65) | 57 (48, 66) | 58 (50,67) | 59 (-2,121) | 33 |
|
|
||||||
| Css (ng/mL) | 28.5 (26.3,30.8) | 29.4 (26.6,32.1) | 28.0 (24.7,31.4) | 28.6 (25.6,31.7) | 25.9 (25.6,226.5) | 18.8 |
|
|
||||||
| AUC (hr•ng/mL) | 685 (631,739) | 705 (639,770) | 673 (593, 753) | 687 (614,761) | 621 (-614,5437) | 450 |
|
| ||||||
| HB | ||||||
| Cmax (ng/mL) | 464 (406,522) | 592 (493,690) | 386a (330, 442) | 405a (352,459) | 291 (130,452) | 137 |
|
|
||||||
| Css (ng/mL) | 397 (347,447) | 501 (410,591) | 333b (285,381) | 349b (301,397) | 258 (-992,1509) | 115 |
|
|
||||||
| AUC (hr•ng/mL) | 9524 (8319,10729) | 12015 (9852,14177) | 7996a (6833,9149) | 8375b (7219,9531) | 6200 (-23812,36212) | 2753 |
|
|
||||||
| HB/BUP | 14.4 (12.6,16.2) | 17.4 (14.1,20.8) | 12.5c (10.6, 14.4) | 12.8c (10.8,14.8) | 12.2 (-34.2,58.6) | 6.1 |
|
| ||||||
| EB | ||||||
| Cmax (ng/mL) | 38 (35,42) | 43 (37,49) | 35 (31,41) | 36 (31,41) | 38 (-1,77) | 22 |
|
|
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| Css (ng/mL) | 32 (29,36) | 36 (30,42) | 30 (25,34) | 30 (26,34) | 31 (-183,246) | 19 |
|
|
||||||
| AUC (hr·ng/mL) | 772 (689,856) | 868 (727,1008) | 713 (609,817) | 721 (618,825) | 753 (-4393,5899) | 444 |
|
|
||||||
| EB/BUP | 1.15 (1.05,1.25) | 1.24 (1.07,1.42) | 1.09 (0.96,1.22) | 1.08 (0.93,1.23) | 1.30 (-0.48,3.08) | 0.99 |
|
| ||||||
| TB | ||||||
| Cmax (ng/mL) | 208 (181,236) | 241 (190,293) | 188 (157, 218) | 188 (159,216) | 222 (-9,453) | 122 |
|
|
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| Css (ng/mL) | 175 (150,200) | 204 (153,255) | 158 (132,182) | 157 (132,182) | 190 (-1220,1599) | 108 |
|
|
||||||
| AUC (hr•ng/mL) | 4209 (3612,4807) | 4893 (3661,6126) | 3789 (3170, 4407) | 3775 (3178,4371) | 4549 (-29275,38373) | 2582 |
|
|
||||||
| TB/BUP | 6.21 (5.53,6.90) | 6.93 (5.53,8.32) | 5.77 (5.04, 6.50) | 5.62 (4.82,6.42) | 7.50 (3.78,11.23) | 5.73 |
Significant differences compared to no reduced function allele group
a
P = 0.005
b
P < 0.001
c
P = 0.01