Table 3.
24-hour Urine Bupropion and Metabolite Excretion
| 24-hour recovery (nmol, mean = 95%) | ||||||
|---|---|---|---|---|---|---|
| All (N=42) | No reduced function allele (N=16) | With reduced function allele(s) (N=26) | *6 allele (N= 23) | *18 allele (N= 2) | *6/18 allele (N= 1) | |
| BUP | 2087 (1512,2662) | 2568 (1169,3968) | 1790 (1346,2234) | 1800 (1305,2295) | 1301 (-3755,6356) | 2543 |
| HB – free | 3672 (2782,4561) | 4698 (2776,6619) | 3041 (2187,3895) | 3207 (2257,4157) | 1736 (884,2587) | 1824 |
| HB – gluc | 12283 (10393,14173) | 14902 (11602,18201) | 12283 (8450, 12892) | 11068 (8612,13525) | 9039 (-4153,22232) | 4787 |
| EB–free | 4872 (3753,5991) | 6186 (3634,8738) | 4063 (3107,5020) | 4067 (2996,5138) | 3711 (-15768,23191) | 4692 |
| EB – gluc | 1718 (1438,1998) | 1905 (1354,2456) | 1603 (1278,1928) | 1602 (1235,1969) | 1763 (-2118,5643) | 1304 |
| TB–free | 38376 (27180,49572) | 53034 (25558,80501) | 29356 (22366,36344) | 28990 (21286,36694) | 32492 (-163420,228404) | 31495 |
| TB – gluc | 4778 (2539,7017) | 7731 (2047,13415) | 2961 (1862,4060) | 2877 (1788,3966) | 5402 (-39287,50083) | 0 |
| % Daily Bupropion dose | ||||||
| All (N=42) | No reduced function allele (N=16) | With reduced function allele(s) (N=26) | *6 allele (N= 23) | *18 allele (N= 2) | *6/18 allele (N= 1) | |
| BUP | 0.33% (0.24%,0.43%) | 0.41% (0.19%,0.63%) | 0.29% (0.22%,0.36%) | 0.29% (0.21%,0.37%) | 0.21% (-0.60%,1.02%) | 0.41% |
| HB – free | 0.59% (0.45%,0.73%) | 0.75% (0.44%,1.06%) | 0.49% (0.35%,0.62%) | 0.51% (0.36%,0.67%) | 0.28% (0.14%,0.41%) | 0.29% |
| HB – gluc | 1.97% (1.66%,2.27%) | 2.38% (1.86%,2.91%) | 1.70% (1.35%,2.06%) | 1.77% (1.38%,2.16%) | 1.45% (-0.66%,3.56%) | 0.77% |
| EB–free | 0.78% (0.60%,0.96%) | 0.99% (0.58%,1.40%) | 0.65% (0.50%,0.80%) | 0.65% (0.48%,0.82%) | 0.59% (-2.52%,3.71%) | 0.75% |
| EB – gluc | 0.27% (0.23%,0.32%) | 0.30% (0.22%,0.39%) | 0.26% (0.20%,0.31%) | 0.26% (0.20%,0.32%) | 0.28% (-0.34%,0.90%) | 0.21% |
| TB–free | 6.14% (4.35%,7.93%) | 8.49% (4.09%,12.88%) | 4.70% (3.58%,5.82%) | 4.64% (3.41%,5.87%) | 5.20% (-26.18%,36.54%) | 5.04% |
| TB – gluc | 0.76% (0.41%,1.12%) | 1.24% (0.33%,2.15%) | 0.47% (0.30%,0.65%) | 0.46% (0.29%,0.64%) | 0.86% (6.29%,8.01%) | 0.00% |
| Renal clearance (ml/min/kg) | ||||||
| All (N=42) | No reduced function allele (N=16) | With reduced function allele(s) (N=23) | *6 allele (N= 23) | *18 allele (N= 2) | *6/18 allele (N= 1) | |
| BUP | 0.17 (0.12,0.21) | 0.18 (0.10,0.26) | 0.16 (0.10,0.21) | 0.16 (0.09,0.22) | 0.10 (-0.33,0.53) | 0.28 |
| HB | 0.02 (0.02,0.03) | 0.03 (0.02,0.04) | 0.03 (0.02,0.03) | 0.03 (0.02,0.03) | 0.01 (-0.04,0.06) | 0.04 |
| EB | 0.36 (0.28,0.45) | 0.41 (0.26,0.56) | 0.34 (0.24,0.43) | 0.34 (0.23,0.45) | 0.20 (-0.12,0.52) | 0.53 |
| TB | 0.50 (0.39,0.61) | 0.58 (0.36,0.81) | 0.44 (0.33,0.56) | 0.45 (0.32,0.58) | 0.29 (-0.14,0.73) | 0.62 |
Bold – significant difference compared to no reduced function allele group, p = 0.03.