Figure 1.

Severity of cerulein-induced CP in B6N and B6J substrains. Mice were subjected to three episodes of cerulein treatment over 5 days to induce CP and were sacrificed at 3 days after the last treatment. A: Loss of pancreatic weight relative to total body weight indicates significant pancreatic atrophy. B6J mice have significantly more pancreatic atrophy, compared with B6N mice. B: Histological changes in H&E-stained pancreas of B6N and B6J mice after induction of CP. Pancreas from B6N and B6J mice after control saline treatment shows no abnormalities. After cerulein treatment, pancreas from both B6J and B6N mice shows disrupted acinar architecture, dedifferentiation to tubular complexes, and interstitial inflammation; all of these parameters were more severe in B6J than B6N mice (Table 2). Data are expressed as means ± SEM. n = 6 mice per group. ^∗∗∗P < 0.001. Original magnification, ×200.