Table 5.
Highly Differentially Regulated Pancreatic Genes in the Cerulein-Induced Model of CP
| Gene | Gene symbol | EntrezGene ID | Chr | Fold change, CP vs control B6J; B6N |
|---|---|---|---|---|
| Adenylate cyclase 7 | Adcy7 | 11513 | 8 | 11.3; 3.5 |
| Alpha 1 microglobulin; bikunin | Ambp | 11699 | 4 | 12.9; 10.0 |
| Annexin A10∗ | Anxa10 | 26359 | 8 | 28.0; 10.8 |
| Anterior gradient 2 | Agr2 | 23795 | 12 | 38.8; 21.9 |
| Antigen identified by monoclonal antibody Ki 67 | Mki67 | 17345 | 7 | 10.0; 4.5 |
| Apolipoprotein E | Apoe | 11816 | 7 | 13.0; 14.4 |
| Asporin∗ | Aspn | 66695 | 13 | 11.4; 2.5 |
| Baculoviral IAP repeat-containing 5 | Birc5 | 11799 | 11 | 30.3; 20.3 |
| Biglycan | Bgn | 12111 | X | 10.9; 3.2 |
| Carbonic anhydrase 9 | Car9 | 230099 | 4 | 11.0; 6.8 |
| Cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | Cilp | 214425 | 9 | 23.7; 27.0 |
| Cathepsin K | Ctsk | 13038 | 3 | 11.3; 12.4 |
| Cathepsin S | Ctss | 13040 | 3 | 13.9; 11.9 |
| CD14 antigen | Cd14 | 12475 | 18 | 10.3; 8.2 |
| CD44 antigen | Cd44 | 12505 | 2 | 13.6; 12 |
| CD52 antigen | Cd52 | 23833 | 4 | 10.9; 5.8 |
| CDC28 protein kinase 1b | Cks1b | 54124 | 3 | 14.4; 11.8 |
| CDC28 protein kinase regulatory subunit 2 | Cks2 | 66197 | 4 | 10.3; 11.3 |
| Cell division cycle 20 | Cdc20 | 107995 | 4 | 10.8; 7.5 |
| Centromere protein A | Cenpa | 12615 | 5 | 10.0; 8.0 |
| Ceruloplasmin | Cp | 12870 | 3 | 4.8; 11.5 |
| Chemokine (C-C motif) ligand 6 | Ccl6 | 20305 | 11 | 11.9; 3.5 |
| Chemokine (C-C motif) ligand 8∗ | Ccl8 | 20307 | 11 | 61.5; 12.9 |
| Claudin 2 | Cldn | 12738 | X | 20.1; 23.4 |
| Complement component 1, q subcomponent, beta polypeptide | C1qb | 12260 | 4 | 13.7; 7.2 |
| Complement component 1, q subcomponent, C chain | C1qc | 12262 | 4 | 14.6; 13.4 |
| Complement component 3a receptor 1 | C3ar1 | 12267 | 6 | 4.1; 10.1 |
| Complement component factor i | Cfi | 12630 | 3 | 8.4; 13.7 |
| Cyclin-dependent kinase 1 | Cdk1 | 12534 | 10 | 11.3; 7.4 |
| DNA segment, Chr 17, human D6S56E5 | D17H6S56E-5 | 110956 | 17 | 20.0; 35.3 |
| EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | Emr1 | 13733 | 17 | 11.0; 8.5 |
| Expressed sequence AU020206 | AU020206 | 101757 | 7 | 7.1; 12.5 |
| Fc receptor, IgE, high affinity I, gamma polypeptide | Fcer1g | 14127 | 1 | 12.3; 6.1 |
| Fc receptor, IgG, low affinity Iib | Fcgr2b | 14130 | 1 | 11.6; 7.6 |
| Flap structure specific endonuclease 1 | Fen1 | 14156 | 19 | 5.6; 10.3 |
| Gastric intrinsic factor | Gif | 14603 | 19 | 15.2; 16.3 |
| Group specific component | Gc | 14473 | 5 | 17.1; 9.4 |
| Growth arrest specific 5 | Gas5 | 14455 | 1 | 8.2; 17.7 |
| Helicase, lymphoid specific | Hells | 15201 | 19 | 10.7; 4.5 |
| Hexosaminidase B | Hexb | 15212 | 13 | 10.4; 9.9 |
| Integral membrane protein 2A | Itm2a | 16431 | X | 15.9; 17.3 |
| Inter-alpha (globulin) inhibitor H5 | Itih5 | 209378 | 2 | 4.6; 11.5 |
| Interferon activated gene 203 | Ifi203 | 15950 | 1 | 10.3; 8.3 |
| Interferon, alpha-inducible protein 27 like 2A∗ | Ifi27l2a | 76933 | 12 | 10.0; 2.6 |
| Interferon activated gene 205 | Ifi205 | 226695 | 1 | 10.5; 6.7 |
| Lectin, galactose binding, soluble 3 | Lgals3 | 16854 | 14 | 16.8; 12.3 |
| Legumain | Lgmn | 19141 | 12 | 10.0; 8.4 |
| Lipocalin 2 | Lcn2 | 16819 | 2 | 25.0; 19.1 |
| Lumican | Lum | 17022 | 10 | 12.6; 14.1 |
| Lymphocyte antigen 86 | Ly86 | 17084 | 13 | 14.3; 8.0 |
| Lysozyme 1 | Lyz1 | 17110 | 10 | 11.6; 9.6 |
| Lysozyme 2 | Lyz2 | 17105 | 10 | 15.3; 11.3 |
| Lysyl oxidase | Lox | 16948 | 18 | 10.1; 8.6 |
| Macrophage expressed gene 1 | Mpeg1 | 17476 | 19 | 11.1; 15.4 |
| Major urinary protein 2 | Mup2 | 17841 | 4 | 31.2; 53.4 |
| Matrix Gla protein | Mgp | 17313 | 15 | 9.6; 11.1 |
| Matrix metallopeptidase 2 | Mmp2 | 17390 | 8 | 10.0; 16.2 |
| Matrix metallopeptidase 7∗ | Mmp7 | 17393 | 9 | 16.0; 3.8 |
| Membrane-spanning 4-domains, subfamily A, member 6B | Ms4a6b | 69774 | 19 | 14.3; 8.3 |
| Membrane-spanning 4-domains, subfamily A, member 7 | Ms4a7 | 109225 | 19 | 29.5; 25.9 |
| Mesoderm specific transcript | Mest | 17294 | 6 | 10.8; 12.7 |
| Minichromosome maintenance deficient 4 homolog (S. cerevisiae) | Mcm4 | 17217 | 16 | 8.8; 19.1 |
| Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | Mcm5 | 17218 | 8 | 23.0; 17.8 |
| Minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S.cerevisiae) | Mcm6 | 17219 | 1 | 22.8; 19.5 |
| Minichromosome maintenance deficient 7 (S. cerevisiae) | Mcm7 | 17220 | 16 | 10.4; 6.6 |
| Non-SMC condensin II complex, subunit G2 | Ncapg2 | 76044 | 12 | 10.5; 7.2 |
| Osteoglycin | Ogn | 18295 | 13 | 12.7; 6.7 |
| PDZ binding kinase | Pbk | 52033 | 14 | 12.3; 9.7 |
| Periostin, osteoblast specific factor | Postn | 50706 | 3 | 37.8; 40.7 |
| Placenta-specific 8 | Plac8 | 231507 | 5 | 11.8; 5.8 |
| Pleckstrin homology-like domain, family B, member 2 | Phldb2 | 208177 | 16 | 10.2; 13.2 |
| Pleiotrophin | Ptn | 19242 | 6 | 10.0; 12.3 |
| Procollagen, type I, alpha 2 | Col1a2 | 12843 | 6 | 6.3; 11.2 |
| Procollagen, type III, alpha 1 | Col3a1 | 12825 | 1 | 7.7; 10.4 |
| Procollagen, type V, alpha 2 | Col5a2 | 12832 | 1 | 6.2; 10.0 |
| Receptor transporter protein 4 | Rtp4 | 67775 | 16 | 11.4; 6.1 |
| Regenerating islet-derived 3 gamma∗ | Reg3g | 19695 | 6 | 7.9; 21.2 |
| Retinol binding protein 1, cellular | Rbp1 | 19659 | 9 | 13.5; 7.6 |
| RIKEN cDNA 1810009J06e | 1810009J06Rik | 73626 | 6 | 160.9; 97.1 |
| Serine (or cysteine) peptidase inhibitor, clade A, member 6 | Serpina6 | 12401 | 12 | 18.6; 6.1 |
| Similar to histone 2a | MGC73635 | 665433 | 13 | 12.3; 21.3 |
| Stathmin 1 | Stmn1 | 16764 | 4 | 11.1; 10.2 |
| Sulfatase 2 | Sulf2 | 72043 | 2 | 9.1; 17.3 |
| Tetraspanin 1 | Tspan1 | 66805 | 4 | 10.8; 6.0 |
| Thymosin, beta 10 | Tmsb10 | 19240 | 7 | 10.1; 8.1 |
| Topoisomerase (DNA) II alpha | Top2a | 21973 | 11 | 11.5; 13.4 |
| TYRO protein tyrosine kinase binding protein | Tyrobp | 22177 | 7 | 22.6; 11.6 |
| Ubiquitin-conjugating enzyme E2C | Ube2c | 68612 | 2 | 12.9; 13.4 |
| Widely-interspaced zinc finger motif | Wiz | 22404 | 17 | 15.8; 10.0 |
| Galanin | Gal | 14419 | 19 | −21.1; −11.7 |
| Hepcidin antimicrobial peptide 2 | Hamp2 | 66438 | 7 | −42.3; −21.0 |
| Inter alpha-trypsin inhibitor, heavy chain 4∗ | Itih4 | 16427 | 14 | −16.8; −12.7 |
| RIKEN cDNA 1810007D17 gene | 1810007D17Rik | 69055 | 19 | −17.7; −10.5 |
| Two pore segment channel 2 | Tpcn2 | 233979 | 7 | −14.2; −6.3 |
Only transcripts that were regulated more than 10-fold in at least one of the substrains (B6J or B6N) are shown. P < 0.01, cerulein-treated versus control probes. A minus sign in the fold change column indicates downregulation in B6J versus B6N.
∗
Expressed at significantly different level (fold change >2) between B6J and B6N after cerulein treatment in the CP mouse model. P < 0.05.