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. 2013 Sep;183(3):796–807. doi: 10.1016/j.ajpath.2013.06.008

Figure 6.

Figure 6

CD163+, CD34, and procollagen+ cells accumulate in the skin of NSF patients. A: Only a small number of CD163+ cells (brown) were present in the skin of end-stage renal disease (ESRD) patients with no NSF control. B: CD34 staining of ESRD patient (control) skin, showing no staining for CD34-positive cells. C: Extensive infiltration of spindled CD163+ macrophages (brown) in the lesional dermis of a patient with NSF. D: A CD163+ spindled macrophage (brown) in close juxtaposition with a CD34+ fibrocyte (red) in the dermis of a patient with NSF. In this biopsy specimen, one of the cells was also double positive for CD163 (brown) and CD34 (red). E: High-power view showing procollagen-1 (brown) and CD163 (brown) double-positive cells in the dermis of a NSF patient. F: A vessel-like (V) structure in the dermis of a NSF patient lined by CD163 (brown) and procollagen-1 (red) double-positive cells. Original magnification, ×100 (A and C); ×200 (B); ×400 (F); ×600 (D and E).