Table 4. Hazard ratios of gender, age and lifestyle for MS by genotype (univariate analysis).
| NCEP-ATPIII | Japanese definition | |||||||
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |||
| Sex | Female | 1.00 | 1.00 | |||||
| Male | 4.46 | 2.95–6.74 | 0.00 | 7.01 | 3.86–12.75 | 0 | ||
| Age | 1.02 | 1.00–1.04 | 0.02 | 1.01 | 0.99–1.03 | 0.53 | ||
| rs9939609 | Additive model | TT | 1.00 | 1.00 | ||||
| TA | 1.52 | 1.10–2.08 | 0.01 | 1.38 | 0.93–2.03 | 0.10 | ||
| AA | 1.31 | 0.63–2.70 | 0.46 | 1.33 | 0.58–3.05 | 0.51 | ||
| Dominant model | TT | 1.00 | 1.00 | |||||
| TA + AA | 1.49 | 1.09–2.02 | 0.01 | 1.37 | 0.95–1.99 | 0.09 | ||
| Recessive model | TT + TA | 1.00 | 1.00 | |||||
| AA | 1.140 | 0.56–2.32 | 0.72 | 1.19 | 0.52–2.71 | 0.68 | ||
| rs1121980 | Additive model | GG | 1.00 | 1.00 | ||||
| GA | 1.57 | 1.14–2.16 | 0.01 | 1.19 | 0.80–1.74 | 0.39 | ||
| AA | 1.78 | 0.92–3.41 | 0.08 | 1.82 | 0.93–3.55 | 0.07 | ||
| Dominant model | GG | 1.00 | 1.00 | |||||
| GA + AA | 1.60 | 1.17–2.16 | 0.00 | 1.27 | 0.88–1.83 | 0.2 | ||
| Recessive model | GG + GA | 1.00 | 1.00 | |||||
| AA | 1.520 | 0.80–2.89 | 0.20 | 1.7 | 0.89–3.26 | 0.11 | ||
| rs1558902 | Additive model | TT | 1.00 | 1.00 | ||||
| TA | 1.33 | 0.97–1.83 | 0.08 | 1.37 | 0.93–2.03 | 0.11 | ||
| AA | 1.76 | 0.98–3.15 | 0.06 | 1.88 | 0.9–3.91 | 0.09 | ||
| Dominant model | TT | 1.00 | 1.00 | |||||
| TA + AA | 1.39 | 1.02–1.88 | 0.04 | 1.44 | 0.99–2.08 | 0.05 | ||
| Recessive model | AT + TT | 1.00 | 1.00 | |||||
| AA | 1.57 | 0.89–2.77 | 0.12 | 1.69 | 0.82–3.47 | 0.15 | ||
| Alcohol drinking habit | No drinking | 1.00 | 1.00 | |||||
| Occasionally | 1.70 | 1.16–2.49 | 0.01 | 1.37 | 0.87–2.15 | 0.18 | ||
| Nearly every day | 2.36 | 1.62–3.45 | 0.00 | 1.99 | 1.28–3.10 | 0 | ||
| Smoking habit | Never smoked | 1.00 | 1.00 | |||||
| Ex-smokers | 1.30 | 0.59–2.83 | 0.51 | 1.92 | 0.86–4.28 | 0.11 | ||
| Current smokers | 2.81 | 2.05–3.85 | 0.00 | 2.92 | 1.98–4.30 | 0 | ||
| Balance of food | Eat various food | 1.00 | 1.00 | |||||
| Consider balance slightly | 0.57 | 0.39–0.83 | 0.00 | 0.62 | 0.39–0.96 | 0.03 | ||
| Rarely consider balance | 1.01 | 0.70–1.45 | 0.97 | 0.99 | 0.64–1.55 | 0.97 | ||
| Exercise habit | Frequently | 1.00 | 1.00 | |||||
| Sometimes | 1.01 | 0.54–1.90 | 0.96 | 1.05 | 0.51–2.17 | 0.89 | ||
| No exercise | 0.94 | 0.52–1.71 | 0.84 | 0.8 | 0.4–1.61 | 0.53 | ||
| Sleeping habit | Sufficiently | 1.00 | 1.00 | |||||
| Normal | 0.75 | 0.52–1.10 | 0.14 | 0.96 | 0.60–1.55 | 0.88 | ||
| Insufficiently | 0.68 | 0.38–1.22 | 0.20 | 0.83 | 0.40–1.71 | 0.6 | ||
CI, confidence interval; MS, metabolic syndrome; NCEP-ATPIII, National Cholesterol Education Program-Adult Treatment panel III.