Table 6. Association of FTO genotype with MS.
Method | Subject | Definition of MS | SNP | Association | |
Present study | Cohort study | Japanese | Japanese definition | rs9939609 | – |
(Izumo region, Shimane) | rs1121980 | – | |||
rs1558902 | + | ||||
NCEP-ATPIII | rs9939609 | + | |||
rs1121980 | + | ||||
rs1558902 | + | ||||
Shimaoka et al., 2010 | Cross-sectional study | Japanese | Japanese definition | rs9939609 | – |
(Tanno-Sobetsu, Hokkaido) | rs1121980 | – | |||
rs1558902 | – | ||||
Tabara et al., 2009 | Case-control study | Japanese | NCEP-ATPIII | rs9939609 | – |
(Ehime) | |||||
Sjögren et al., 2008 | Cohort study | Swedish | Ordinal | rs9939609 | + |
(reference to NCEP-ATPIII, IDF) | |||||
Al-Attar et al., 2008 | Meta-analysis | South Asian | IDF | rs9939609 | + |
Chinese | – | ||||
Oji-Cree | – | ||||
Greenland Inuit | – | ||||
South Asian | NCEP-ATPIII | rs9939609 | – | ||
Chinese | – | ||||
Oji-Cree | – | ||||
Greenland Inuit | + |
FTO, fat mass and obesity associated gene; IDF, International Diabetes Federation; MS, metabolic syndrome; NCEP-ATPIII, National Cholesterol Education Program-Adult Treatment panel III; SNP, single nucleotide polymorphism.