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. Author manuscript; available in PMC: 2013 Sep 5.
Published in final edited form as: Science. 2013 May 31;340(6136):1110–1113. doi: 10.1126/science.1235532

Figure 1.

Figure 1

Binding sites between the CENP-C central region on the chimeric nucleosome mapped by methyl-based NMR. (A) Histone methyl chemical shift perturbation (CSP) upon CENP-C426-537 binding. (B) Effects on methyl groups by paramagnetic spin labels in CENP-C484-537. (C) Nucleosome structure showing representative side chains (black balls) whose methyl groups display large changes in (A) or (B), and approximate locations of CENP-C residues (arrows). E133 in H3 is used to represent L133 in H31-132-LEEGLG.