. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2013 Aug;72(8):791–800. doi: 10.1097/NEN.0b013e31829ecc89

Table 1.

Summary of Dendritic Spine Characteristics as a Function of Distance from the Plaque (n = 134)

Spine Parameter	Distance from Plaque		F (df)	p
	0–6 μm	6–24 μm
	n = 110119 Spines	n = 720515 spines
Density, μm⁻³
Mean (SD)	0.161 (0.12)	0.2556 (0.10)	629.63	< 0.001
Range	< 0.01–0.52	< 0.01–0.53	(1,1720)
Volume, μm³
Mean (SD)	0.076 (0.03)	0.079 (0.03)	13.80	< 0.001
Range	0.01–0.19	0.02–0.20	(1,1492)
Surface Area, μm²
Mean (SD)	1.41 (0.44)	1.47 (0.44)	23.47	< 0.001
Range	0.27–3.18	0.61–3.04	(1,1492)
Shape Complexity, Sphericity⁻¹
Mean (SD)	1.64 (0.09)	1.66 (0.08)	57.04	< 0.001
Range	1.37–2.02	1.46–1.89	(1,1508)
Normalized Total Phalloidin Intensity per Spine, gray level
Mean (SD)	29443 (26249)	24287 (18620)	25.08	< 0.001
Range	68–279006	1832–223278	(1,1558)