Table 2.

Stepwise linear regressions of spine densities starting within the fibrillar Aβ plaque and extending to a distance of 24 μm from the plaque perimeter

Predictor Variable	Distance	Beta	T	P value
Fibrillar Aβ Plaque Mean X-34 Fluorescence Intensity	Plaque	−0.029	−2.595	0.011
	0 – 2 μm	−0.051	−3.889	<0.001
	2 – 4 μm	−0.040	−3.349	0.001
	4 – 6 μm	−0.022	−2.162	0.033
	6 – 8 μm	−0.012	−1.308	0.194
	8 – 10 μm	−0.0002	−0.018	0.985
	10 – 12 μm	0.007	0.872	0.385
	12 – 14 μm	0.010	1.147	0.254
	14 – 16 μm	0.011	1.208	0.229
	16 – 18 μm	0.008	0.883	0.379
	18 – 20 μm	0.009	1.043	0.299
	20 – 22 μm	0.019	1.993	0.049
	22 – 24 μm	0.011	1.202	0.232
Aβ-Immunoreactivity (6E10 Fluorescence Intensity)	Plaque	−0.005	−0.972	0.333
	0 – 2 μm	−0.017	−2.196	0.030
	2 – 4 μm	−0.020	−1.945	0.054
	4 – 6 μm	−0.009	−0.965	0.336
	6 – 8 μm	0.001	0.098	0.922
	8 – 10 μm	0.005	0.650	0.517
	10 – 12 μm	0.002	0.197	0.844
	12 – 14 μm	0.005	0.557	0.578
	14 – 16 μm	0.008	0.996	0.321
	16 – 18 μm	0.009	1.154	0.251
	18 – 20 μm	0.013	1.627	0.106
	20 – 22 μm	0.014	1.619	0.108
	22 – 24 μm	0.016	2.002	0.047
Fibrillar Aβ Plaque Volume	Plaque	−5.546E-6	−0.678	0.499
	0 – 2 μm	−7.589E-6	−0.748	0.456
	2 – 4 μm	−4.450E-6	−0.469	0.640
	4 – 6 μm	−5.987E-6	−0.746	0.457
	6 – 8 μm	−4.120E-6	−0.570	0.570
	8 – 10 μm	−3.875E-6	−0.571	0.569
	10 – 12 μm	−1.388E-6	−0.202	0.840
	12 – 14 μm	−1.838E-6	−0.262	0.794
	14 – 16 μm	8.186E-7	0.119	0.905
	16 – 18 μm	2.901E-6	0.409	0.683
	18 – 20 μm	6.298E-6	0.921	0.359
	20 – 22 μm	−6.737E-6	−0.912	0.364
	22 – 24 μm	6.285E-6	0.981	0.329