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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Aug;72(8):791–800. doi: 10.1097/NEN.0b013e31829ecc89

Table 3.

Association of Spine Morphologic Measures with β-Amyloid and Plaque Features

Dependent Measure Predictor Variable Distance from plaque Edge
0 to 6 μm
F (df) P value
Spine Volume, μm3 Aβ-Immunoreactivity (Normalized Total 6E10 Fluorescence Intensity) 9.313 (1,393) 0.002
Fibrillar Aβ Plaque Volume 0.008 (1,363) 0.929
Fibrillar Aβ Plaque Mean X-34 Fluorescence Intensity 1.527 (1,351) 0.217
Spine Surface area, μm2 Aβ-Immunoreactivity (Normalized Total 6E10 Fluorescence Intensity) 8.643 (1,393) 0.003
Fibrillar Aβ Plaque Volume 0.060 (1,356) 0.807
Fibrillar Aβ Plaque Mean X-34 Fluorescence Intensity 1.284 (1,343) 0.258
Spine Shape Complexity, Sphericity−1 Aβ-Immunoreactivity (Normalized Total 6E10 Fluorescence Intensity) 8.760 (1,378) 0.003
Fibrillar Aβ Plaque Volume 1.895 (1,297) 0.170
Fibrillar Aβ Plaque Mean X-34 Fluorescence Intensity 0.013 (1,273) 0.911
Total Phalloidin/Spine, gray level Aβ-Immunoreactivity (Normalized Total 6E10 Fluorescence Intensity) 0.340 (1,390) 0.560
Fibrillar Aβ Plaque Volume 0.144 (1,373) 0.705
Fibrillar Aβ Plaque Mean X-34 Fluorescence Intensity 0.648 (1,364) 0.421

Aβ, β-amyloid.