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. Author manuscript; available in PMC: 2013 Sep 5.
Published in final edited form as: J Neuroimmune Pharmacol. 2011 Apr 5;6(4):466–476. doi: 10.1007/s11481-011-9278-3

Figure 1. Transcriptional and translational control of FHC production.

Figure 1

A depiction of the human FHC promoter region, containing the basal enhancer (B box), Sp1 binding site (A box), an inhibitory region (G-fer), Antioxidant Response Element (ARE), and TSA Responsive Element (LaVaute et al.) (A). Processes illustrated in B regulate translation of FHC mRNA. Iron Regulatory Proteins (IRP) 1 and 2 bind the stem-loop structure of the Iron Responsive Element (IRE) to inhibit translation and are inactivated by high levels of free iron. Mechanisms of iron-mediated IRP inactivation include a loss of IRE binding affinity (IRP1) and protein degradation (IRP2).