Fig. 4.

Efficacy profiling of the 89 oncology drugs against the SUM190 cells. SUM190 cells (1000 cells per well) were incubated with drugs in dose response as a 10-point two-fold dilution series for 72h and cell proliferation assessed by MTT assay as described in Materials and Methods. Each row represents dose response data for a single drug. For each concentration, percent inhibition values were calculated and data normalized to vehicle and no cell control wells. The heat map key indicates red for 100% inhibition through to green for 0% inhibition. Drugs are listed in plating order and a representative experiment is shown. Cells were profiled versus the NCI Oncology set for a minimum of two independent screens.