. Author manuscript; available in PMC: 2014 Aug 28.

Published in final edited form as: Cancer Lett. 2013 May 17;337(1):77–89. doi: 10.1016/j.canlet.2013.05.017

Table 5.

Top Drugs from NCI Approved Oncology Set with efficacy on lapatinib-resistant rSUM149 cells

Drug Name	Type	Mechanism of action
Dactinomycin	Chromopeptide antineoplastic antibiotic	Intercalates DNA; causes single- strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II.
Plicamycin	Antibiotic	Intercalates DNA
Bortezomib	Dipeptide boronic acid analogue	Proteasome inhibitor
Doxorubicin	Anthracycline	Intercalates DNA; inhibits topoisomerase II; forms oxygen free radicals
Daunorubicin	Anthracycline	Inhibits topoisomerase II
Fludarabine	Fluorinated nucleotide antimetabolite analog	DNA synthesis inhibitor
Vorinostat	Synthetic hydroxamic acid	HDAC inhibitor
Mitoxantrone	Anthracenedione antibiotic	Intercalates DNA; inhibits topoisomerase II;
Mitomycin C	Antineoplastic antibiotic	Generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links