Table 5.
Drug Name | Type | Mechanism of action |
---|---|---|
Dactinomycin | Chromopeptide antineoplastic antibiotic |
Intercalates DNA; causes single- strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. |
Plicamycin | Antibiotic | Intercalates DNA |
Bortezomib | Dipeptide boronic acid analogue |
Proteasome inhibitor |
Doxorubicin | Anthracycline | Intercalates DNA; inhibits topoisomerase II; forms oxygen free radicals |
Daunorubicin | Anthracycline | Inhibits topoisomerase II |
Fludarabine | Fluorinated nucleotide antimetabolite analog |
DNA synthesis inhibitor |
Vorinostat | Synthetic hydroxamic acid |
HDAC inhibitor |
Mitoxantrone | Anthracenedione antibiotic |
Intercalates DNA; inhibits topoisomerase II; |
Mitomycin C | Antineoplastic antibiotic |
Generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links |