Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Three-Hybrid Transcriptional Switch Model and Structures of Rapamycin Compounds.
A, The Gal4 DNA-binding domain is fused to FKBP and the Gal4 activation domain is fused to an FRB library. The fusion proteins are colocalized only in the presence of a rapamycin analog, reconstituting the transcription factor and activating expression of the reporter gene.
B, The molecular structures of rapamycin and its analogs with the FRB- and FKBP-binding regions highlighted. Me = methyl.
