Table 2.
Nodes leading to greatest change in estimated effects and average fold changes in estimated treatment effects when single treatment nodes are removed
| Network | Node leading to largest Brier score* | Connectivity of removed node | Removal of largest expected impact node | Removal of other active intervention nodes | |||
|---|---|---|---|---|---|---|---|
| Average fold change | Largest fold change | Average fold change | Largest fold change | ||||
| Change in top three ranked treatments: | |||||||
| Brown 200616 | Cox 2 preferentials (20%) | 3 (max 4) | 1.83 | 3.13 | 1.38 | 4.40 | |
| Cipriani 200917 | Fluoxetine (0%) | 11 (max) | 1.06 | 1.18 | 1.03 | 1.16 | |
| Cooper 200618 | Fixed low dose warfarin+aspirin (0%) | 4 (max 7) | 1.25 | 2.65 | 1.06 | 1.60 | |
| Golfinopoulos 200721 | Fluorouracil (0%) | 5 (max 7)† | 1.03 | 1.05 | 1.01 | 1.09 | |
| Imamura 201022 | Pelvic floor muscle training+biofeedback (5%) | 6 (max 7) | 1.22 | 1.40 | 1.07 | 2.18 | |
| Mauri 200825 | Standard dose anthracycline (0%) | 10 (max) | 1.05 | 1.12 | 1.01 | 1.09 | |
| Mills 2012 (6 mth)27 | Low dose nicotine replacement therapy (0%) | 4 (max) | 1.12 | 1.39 | 1.01 | 1.03 | |
| Sciarretta 201129 | Calcium channel blockers (1%) | 6 (max) | 1.27 | 1.53 | 1.04 | 1.31 | |
| Wang 201031 | Chlorhexidine and silver sulfadiazine (0%) | 4 (max) | 1.27 | 4.64 | 1.01 | 1.08 | |
| No changes in top three ranked treatments: | |||||||
| Ara 200914 | Simvastatin 40 mg (21%) | 4 (max) | 1.13 | 1.19 | 1.04 | 1.11 | |
| Bansback 200915 | Adalimumab (0%) | 2 (max 3) | 1.08 | 1.32 | 1.01 | 1.02 | |
| Dias 201019 | Accelerated alteplase (0%) | 7 (max) | 1.08 | 1.16 | 1.03 | 1.07 | |
| Elliot 200720 | Angiotensin converting enzyme inhibitors (22%) | 4 (max 5) | 1.08 | 1.12 | 1.02 | 1.06 | |
| Kyrgiou 200623 | Platinum monotherapy (0%) | 6 (max) | 1.08 | 1.25 | 1.02 | 1.13 | |
| Lam 200824 | Implantable cardioverter defibrillator (9%) | 3 (max 4)† | 1.03 | 1.07 | 1.01 | 1.04 | |
| Mills 201126 | Inhaled corticosteroids (0%) | 3 (max 6) | 1.01 | 1.02 | 1.00 | 1.01 | |
| Psaty 199728 | Diuretics (10%) | 5 (max) | 1.06 | 1.14 | 1.03 | 1.08 | |
| Thijs 200830 | Aspirin (0%) | 4 (max) | 1.03 | 1.04 | 1.01 | 1.03 | |
*Probability of being best treatment.
†Most connected node that was removed.