Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| HDAC class | IC50 (nM), Chimera 4 | IC50 (nM), vorinostata | |
|---|---|---|---|
| HDAC1 | I | 86 ± 11 | 306 |
| HDAC2 | I | 231 ± 39 | 232 |
| HDAC3 | I | 19 ± 1 | 132 |
| HDAC4 | IIa | 3982 ± 920 | 76000 |
| HDAC5 | IIa | 3891 ± 681 | 27200 |
| HDAC6 | IIb | 2.7 ± 0.5 | 20 |
| HDAC7 | IIa | 13220 ± 860 | 105000 |
| HDAC8 | I | 2311 ± 251 | 306 |
| HDAC9 | IIa | 28020 ± 1910 | 141000 |
| HDAC10 | IIb | 51 ± 3 | 432 |
| HDAC11 | IV | 224 ± 26 | 200 |
Data from Reaction Biology (Malvern, PA).
