Figure 2. .

Corneal changes at the “epithelium-anterior stroma” level in GK rat corneas highlighted by in vivo CCM. (A–B) Transverse images of the epithelium showing hypersignal and infiltrating cells (white arrowheads) in the corneas of young (A) as old (B) GK rats. (C–D) Frontal images of the basal epithelium, demonstrating focal hyper-reflective areas in diabetic corneas (white arrowheads). (E–F) Frontal images at the epithelium-stroma interface highlighting a hyper-reflective “swelling” in the diabetic corneas (white arrowheads). Scale bar, 100 μm.