Figure 4. .

Corneal changes in the posterior corneas of GK rats highlighted by in vivo CCM. (A–B) Frontal images of the endothelium, demonstrating signs of endothelial cell stresses, as hyper-reflective junctions in young GK rats (A) and cornea guttata (B) in old GK rats. (C–F) Frontal images of the DM, showing hyper-reflective dense deposits in corneal peripheries from both young (C) and old (D, F) GK rats. In old nondiabetic control rat, DM images showed no or sparse (E) hyper-reflective deposits. Scale bar, 100 μm.