Figure 8. .

Histology of the DM abnormalities in human corneas. (A-C) Semi-thin sections of the posterior corneas from diabetic donors, demonstrating abnormal deposits in the posterior part of the DM (A–B, white arrowheads) and endothelial dystrophy associated with cell extension in the limbus region (C, black arrowheads). (D–F) Transmission electron micrographs of the diabetic corneas DM, showing collagen secreted by endothelial cells (white arrowheads), appearing as long-spacing collagen on frontal sections (D) and as fibrils on transverse sections (E). In the limbus region (F), TEM also showed long-spacing collagen fibrils (white arrowheads) between endothelial cell extensions (black arrowheads). En, endothelium; St, stroma.