Figure 3. Effects of AMPH on GluA1-S845 phosphorylation in the rat striatum.
(A) Effects of AMPH on S845 phosphorylation in synaptosomal fractions. (B) Effects of AMPH on S845 phosphorylation in synaptic fractions. (C) Effects of AMPH on S845 phosphorylation in extrasynaptic fractions. Note that AMPH produced overall increases in pS845 proteins in all three membrane preparations. Representative immunoblots are shown left to the quantified data. Rats received a single dose of AMPH (0.5, 5, or 10 mg/kg, i.p.) and were sacrificed 15 min after drug injection for immunoblot analysis. Data are presented as means ± S.E.M. (n = 4 per group). * P < 0.05 versus saline.