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. 2013 Sep 5;9(9):e1003216. doi: 10.1371/journal.pcbi.1003216

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© 2013 Agius et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The relationship between experimental values for Δlog₁₀(k_off) and (A) hotspot descriptors showing highest correlation with Δlog₁₀(k_off) (SuppHSEnergy_KFC2a - changes in hotspot energies in the support region as predicted by KFC2a [30]), (B) molecular descriptor showing highest correlation with Δlog₁₀(k_off) (AP_MPS - the DARS atomic potential [54]), (C) top performing hotspot descriptor for the detection of stabilizing mutants (HSEner_PosCoop_RFSpot – changes in hotspot energies on accounting for positive cooperativity in hotregions) and (D) top performing molecular descriptor for the detection of stabilizing mutants (CP_TB – coarse grained protein-protein docking potential).