Table 1. Summary of hotspot descriptors.

Hotspot descriptor	Description
Int_Energy_1	Change in Total Interface ΔΔG ALA Energy
Int_HS_Energy	Change in Total Interface ΔΔG ALA Energy of Hotspots
No_HS	Change in Number of Hotspots
No_Clusters	Change in Number of Unique Hotregions
MaxClusterSize	Change in Number of Hotspots in Largest Hotregion
AVG_HS_PathLength	Change in Hotspot Coverage
CoreHSEnergy	Change in Total ΔΔG ALA Energy of Hotspots in Core Region
CoreHS	Change in Number of Hotspots in Core Region
RimHSEnergy	Change in Total ΔΔG ALA Energy of Hotspots in Rim Region
RimHS	Change in Number of Hotspots in Rim Region
SuppHSEnergy	Change in Total ΔΔG ALA Energy of Hotspots in Support Region
SuppHS	Change in Number of Hotspots in Support Region
HSEner_PosCoop	Change in Total Hotspot ΔΔG ALA Energy Accounting for Positive Cooperativity in Hotregions
HS_PosCoop	Change in Hotspot Counts Accounting for Positive Cooperativity in Hotregions
HSEner_NegCoop	Change in Total Hotspot ΔΔG ALA Energy Accounting for Negative Cooperativity in Hotregions
HS_NegCoop	Change in Hotspot Counts Accounting for Negative Cooperativity in Hotregions