Table 2. Pearson's Correlation Coefficient (PCC) of hotspot descriptors with experimental Δlog10(koff) for the 713 off-rate mutations in SKEMPI.
Hotspot descriptor | RFHotpoint1 | RFHotpoint2 | KFC2a | KFC2b | RFSpot | RFSpot_KFC2 | Mean PCC | Variance in PCC |
Int_Energy_1 | −0.312 | −0.312 | −0.472 | −0.432 | −0.182 | −0.289 | −0.333 | 0.105 |
No_HS | −0.433 | −0.266 | −0.429 | −0.496 | −0.493 | −0.496 | −0.436 | 0.089 |
Int_HS_Energy | −0.568 | −0.312 | −0.546 | −0.527 | −0.532 | −0.559 | −0.508 | 0.097 |
No_Clusters | 0.101 | −0.069 | −0.075 | −0.272 | −0.284 | −0.285 | −0.147 | 0.159 |
MaxClusterSize | −0.225 | 0.022 | 0.094 | 0.052 | −0.163 | −0.292 | −0.085 | 0.162 |
AVG_HS_PathLength | −0.152 | −0.139 | −0.031 | −0.197 | −0.110 | −0.016 | −0.108 | 0.071 |
CoreHSEnergy | −0.608 | −0.365 | −0.369 | −0.427 | −0.541 | −0.560 | −0.479 | 0.105 |
RimHSEnergy | −0.415 | 0.020 | −0.100 | 0.000 | −0.367 | −0.329 | −0.198 | 0.194 |
SuppHSEnergy | −0.153 | −0.162 | −0.617 | −0.489 | −0.385 | −0.465 | −0.379 | 0.187 |
CoreHS | −0.413 | −0.281 | −0.232 | −0.476 | −0.342 | −0.440 | −0.364 | 0.095 |
RimHS | −0.319 | −0.071 | −0.181 | 0.000 | −0.128 | −0.176 | −0.146 | 0.109 |
SuppHS | −0.156 | −0.153 | −0.430 | −0.344 | −0.480 | −0.441 | −0.334 | 0.146 |
HSEner_NegCoop | −0.487 | −0.282 | −0.475 | −0.260 | −0.414 | −0.514 | −0.405 | 0.109 |
HS_NegCoop | −0.330 | 0.013 | −0.049 | −0.356 | −0.415 | −0.460 | −0.266 | 0.198 |
HSEner_PosCoop | −0.278 | −0.192 | −0.218 | −0.437 | −0.573 | −0.444 | −0.357 | 0.150 |
HS_PosCoop | −0.013 | −0.256 | −0.138 | −0.154 | −0.494 | −0.457 | −0.252 | 0.190 |