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. 2013 Sep 5;9(9):e1003216. doi: 10.1371/journal.pcbi.1003216

Table 2. Pearson's Correlation Coefficient (PCC) of hotspot descriptors with experimental Δlog10(koff) for the 713 off-rate mutations in SKEMPI.

Hotspot descriptor RFHotpoint1 RFHotpoint2 KFC2a KFC2b RFSpot RFSpot_KFC2 Mean PCC Variance in PCC
Int_Energy_1 −0.312 −0.312 −0.472 −0.432 −0.182 −0.289 −0.333 0.105
No_HS −0.433 −0.266 −0.429 −0.496 −0.493 −0.496 −0.436 0.089
Int_HS_Energy −0.568 −0.312 −0.546 −0.527 −0.532 −0.559 −0.508 0.097
No_Clusters 0.101 −0.069 −0.075 −0.272 −0.284 −0.285 −0.147 0.159
MaxClusterSize −0.225 0.022 0.094 0.052 −0.163 −0.292 −0.085 0.162
AVG_HS_PathLength −0.152 −0.139 −0.031 −0.197 −0.110 −0.016 −0.108 0.071
CoreHSEnergy −0.608 −0.365 −0.369 −0.427 −0.541 −0.560 −0.479 0.105
RimHSEnergy −0.415 0.020 −0.100 0.000 −0.367 −0.329 −0.198 0.194
SuppHSEnergy −0.153 −0.162 −0.617 −0.489 −0.385 −0.465 −0.379 0.187
CoreHS −0.413 −0.281 −0.232 −0.476 −0.342 −0.440 −0.364 0.095
RimHS −0.319 −0.071 −0.181 0.000 −0.128 −0.176 −0.146 0.109
SuppHS −0.156 −0.153 −0.430 −0.344 −0.480 −0.441 −0.334 0.146
HSEner_NegCoop −0.487 −0.282 −0.475 −0.260 −0.414 −0.514 −0.405 0.109
HS_NegCoop −0.330 0.013 −0.049 −0.356 −0.415 −0.460 −0.266 0.198
HSEner_PosCoop −0.278 −0.192 −0.218 −0.437 −0.573 −0.444 −0.357 0.150
HS_PosCoop −0.013 −0.256 −0.138 −0.154 −0.494 −0.457 −0.252 0.190