Table 2. The neuromuscular transmission of SOD1(G93A) mice in pre-symptomatic phase of the disease.
| 4-6 weeks old | Pre-symptomatic | |
|---|---|---|
| WT | SOD1(G93A) | |
| n (fiber, mice) | 40, 18 | 40,13 |
| Male | 17, 7 | 31, 10 |
| Female | 23, 11 | 9, 3 |
| Mean age (days) | 38.5 ± 1.08 | 41.2 ± 1.05 |
| RMP (mV) | -69.0 ± 1.74 | -67.6 ± 1.80 |
| EPPs amplitude (mV) | 16.6 ± 1.48 | 24.3 ± 1.61# |
| EPPs amplitude NOR (mV) | 18.3 ± 1.64 | 26.8 ± 1.54# |
| Quantal content NOR | 29.0 ± 1.89 | 38.1 ± 2.42# |
| MEPPs amplitude(mV) | 0.55 ± 0.02 | 0.63 ± 0.02# |
| MEPPs rise-time (ms) | 1.32 ± 0.07 | 1.11 ± 0.08# |
| MEPPs decay time (ms) | 4.00 ± 0.15 | 3.67 ± 0.14 |
| MEPPs frequency (s-1) | 0.64 ± 0.07 | 0.59 ± 0.06 |
| N° of NMJs with GMEPPs | 30 | 33 |
| GMEPPs frequency (s-1) | 0.23 ± 0.06 | 0.44 ± 0.08# |
| Fr(GMEPPs)/Fr(MEPPs) | 2.27 ± 1.35 | 1.86 ± 0.45 |
The values are mean±SEM. Results obtained from SOD1(G93A) and age-matched WT mice were compared (#p<0.05 Mann-Whitney test). EPP, endplate potential; EPP amplitude NOR, endplate potential normalized to a resting membrane potential(RPM) of -75mV; MEPP, miniature endplate potential; Quantal contentNOR, normalized quantal content of EPPs (meanEPPNOR/meanMEPPNOR); Fr(MEPPs), MEPPs frequency; Fr (GMEPPs), GMEPPs frequency; NMJ, neuromuscular junction