Table 3. The neuromuscular transmission of SOD1(G93A) mice in symptomatic phase of the disease.
| 12-15 weeks old | Symptomatic | |
|---|---|---|
| WT | SOD1(G93A) | |
| n (fiber, mice) | 30, 11 | 39, 11 |
| Male | 17, 5 | 21, 5 |
| Female | 13, 6 | 18, 6 |
| Mean age (days) | 98.2 ± 0.78 | 99.6 ± 0.46 |
| RMP (mV) | -64.8 ± 2.50 | -65.8 ± 1.69 |
| EPPs amplitude (mV) | 21.0 ± 2.45 | 18.3 ± 1.88 |
| EPPs amplitude NOR (mV) | 23.6 ± 2.21 | 18.3 ± 1.88 |
| Quantal content NOR | 41.3 ± 3.79 | 35.8 ± 2.74 |
| MEPPs amplitude (mV) | 0.50 ± 0.03 | 0.49 ± 0.03 |
| MEPPs rise-time (ms) | 0.98 ± 0.07 | 1.15 ± 0.07 |
| MEPPs decay-time (ms) | 3.12 ± 0.14 | 3.21 ± 0.13 |
| MEPPs frequency (s-1) | 0.76 ± 0.11 | 0.80 ± 0.11 |
| N° of NMJs with GMEPPs | 16 | 20 |
| GMEPPs frequency (s-1) | 0.44 ± 0.12 | 0.32 ± 0.10 |
| Fr(GMEPPs)/Fr(MEPPs) | 1.58 ± 0.49 | 1.21 ± 0.68 |
The values are mean±SEM. Results obtained from age-matched SOD1(G93A) and WT mice were compared. EPP, endplate potential; EPP amplitude NOR, endplate potential normalized to a resting membrane potential(RPM) of -75mV; MEPP, miniature endplate potential; Quantal contentNOR, normalized quantal content of EPPs(meanEPPNOR/meanMEPPNOR); Fr(MEPPs), MEPPs frequency; Fr (GMEPPs), GMEPPs frequency; NMJ, neuromuscular junction