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. 2013 Sep 5;8(9):e73785. doi: 10.1371/journal.pone.0073785

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© 2013 Turgeon et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Four-month-old control (Ctrl) or conditional intestinal epithelial HDAC1/2 (HDAC1/2ΔIEC) mice were killed 48 h after BrdU peritoneal injection to determine jejunal migration (A) and 14 h after BrdU injection for colonic migration (B). Jejunal (A) or colonic (B) tissue sections were revealed with an antibody against BrdU. The average distance of BrdU-labelled cells from jejunal (C) or colonic (D) crypts was measured (n=3; 20 to 40 villi or colonic glands each). BrdU labelled cells are indicated by arrows. Results represent the mean ± SEM (*p≤0.05). Magnification: 20 X.